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LncRNA-mediated organization of oncogenic chromatin state is a targetable vulnerability in leukemia

Zhenggen Jin Brendan D. Ma Karen Y. T. Chan Diana Lin Debajeet Ghosh Amber Louwagie Luke Saville Joanne Liani Chandra Jennifer M. Grants Yi-Lin Liu Zongmin Liu Leo Escano Se-Wing Grace Cheng Sandra E. Spencer P. Stricker Glenn Edin Fiona Wong Kevin Dong Q. Hoang Quang Thang T. Bui Alexandria Schurer Kim Do T. Chou Oakes Christopher G. Basha Martin Sauvageau S. Hussein Gregg B. Morin Fabiana Perna Florian Kuchenbauer M. Kharas Aly Karsan P. Cullis Ly P. Vu
Aug 2026 · bioRxiv · 0 citations
Biology

TL;DR

This study uncovers a therapeutic vulnerable lncRNA-centric circuitry and provides compelling preclinical evidence for the development and application of a novel RNA targeting-LNP based therapy for treatment of myeloid leukemia.

DOI Semantic Scholar
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