Sep 2026· Human Immunology· Vol 87 11, pp.
112068
· 0 citations· 66 references
Medicine
TL;DR
The current understanding of the biological functions of HLA-G is summarized, with particular emphasis on its genetic polymorphisms, and their immunomodulatory roles in renal allograft rejection and post-transplant infections are discussed.
Abstract
Human leukocyte antigen-G (HLA-G) is a nonclassical major histocompatibility complex (MHC) class Ib molecule that plays a critical role in immune tolerance, primarily by promoting immune escape and inducing T-cell anergy. Early studies of HLA-G focused mainly on its function during pregnancy, where it is essential for maintaining maternal-fetal tolerance. In recent years, accumulating evidence has revealed the broader immunoregulatory functions and mechanisms of HLA-G in a variety of pathological conditions. As a key immunosuppressive molecule, HLA-G has been extensively investigated in the context of organ transplantation. In this review, we summarize the current understanding of the biological functions of HLA-G, with particular emphasis on its genetic polymorphisms, and discuss their immunomodulatory roles in renal allograft rejection and post-transplant infections.
Human leukocyte antigen G (HLA G) is a non-classical HLA class I molecule with, potent tolerogenic activity, mainly restricted to immune-privileged tissues under, physiological conditions. However, aberrant HLA G expression has been increasingly, reported in tumors, where it acts as an immune checkpoint contributing to...
Ignacio Juarez, Sandra Fernández-Uría, Christian Vaquero-Yuste et al.· Human Immunology· 0 citations
The biology, disease-associated functions, and therapeutic targeting of nonclassical MHC-I molecules are synthesized, integrating immune checkpoint blockade, antibody-based therapeutics, and MR1- and CD1-restricted cellular immunotherapies into a unified framework.
It is proposed that selected pathogenic non-HLA antibodies participate in a feed-forward cycle of graft injury, antigen exposure, epitope spreading, and humoral amplification, although this model requires longitudinal validation.
A. Fouza, Maria Daoudaki· Medical Science· 0 citations
Introduction Natural killer cell alloreactivity contributes to the graft-versus-leukemia (GVL) effect of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). However, its importance remains controversial across studies. Methods In this retrospective analysis, we studied NK cell alloreactivity and its as...
Xiangfeng Tang, Hai-Fei Zhou, Weijie Zhang et al.· Frontiers in Immunology· 0 citations
Background HLA-G (Human Leukocyte Antigen-G) is a non-classical molecule belonging to the major histocompatibility complex (MHC) class I family, located on chromosome 6 within the MHC region, which is pivotal in promoting immune tolerance. The immune-suppressive ability of Human Leukocyte Antigen (HLA-G) and its bindin...
Richmond Kwakye, D. Courtin, S. Sakyi et al.· PLoS ONE· 0 citations
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