The findings identify a group of peripheral inflammatory markers associated with AD pathology and suggest that some of these relationships may vary by sex, warranting larger studies to clarify the role of sex in AD pathobiology.
Increased serum p-tau217 and decreased ApoE levels were significantly associated with greater AD severity, suggesting that both biomarkers may serve as complementary noninvasive indicators of disease severity in Alzheimer’s disease.
Ahmed Kadom Kalaf, Khawla A. Shemran, Waleed Azeez AlAmeedy· International Journal of Nut...· 0 citations
The observed findings suggest that investigated miRNAs are not suitable for differentiation between different stages of cognitive impairment, however, miRNAs were associated with typical hallmarks of AD, which supports their important role in neurodegeneration.
David Vogrinc, M. Holcar, M. Lenassi et al.· Scientific Reports· 0 citations
Among patients with isolated AD or isolated CSVD, plasma p-Tau217 is the optimal specific biomarker for the diagnosis of AD and differentiation between AD and cerebral small vessel disease.
Xian-Dong Wang, Jun-Qiu Wu, Xuan Zhang et al.· Frontiers in Neurology· 0 citations
This study provides Class II evidence that plasma NfL/p-tau217 discriminates patients with CJD from those with AD and Diagnosing AD with a single abnormal p-tau plasma biomarker risks misdiagnosing prion diseases as AD.
Thomas Coysh, Rhiannon Laban, Elena Veleva et al.· Neurology· 0 citations
Plasma biomarkers offer a transformative, non-invasive approach to early AD diagnosis and primary care triage, reducing reliance on CSF and PET scans and overcoming demographic and methodological limitations is essential for their widespread clinical adoption.
Małgorzata Witaszczyk, Alicja Sołtan, Natalia Wiktorzak et al.· International Journal of Inn...· 0 citations
These findings highlight the complementary roles of CSF and plasma tau biomarkers in tracking disease progression: CSF biomarkers capture early pathological changes, whereas plasma biomarkers more effectively reflect disease progression within symptomatic stages.
J. Arranz, J. Lantero-Rodríguez, Luisa Sophie Braun-Wohlfahrt et al.· EBioMedicine· 1 citation
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