Sep 2026· Ugeskrift for læger· Vol 188 37, pp. 1-10· 0 citations
Medicine
TL;DR
Treatment differs from other inflammatory demyelinating CNS diseases such as multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) despite overlapping symptoms despite overlapping symptoms.
Abstract
MOG-antibody-associated disease (MOGAD) is a rare inflammatory demyelinating CNS condition. Diagnosis is based on core clinical symptoms supported by additional clinical/MRI data if necessary, depending on the antibody titer in the blood. The clinical presentation is age-dependent. Due to its recent recognition, management is not clearly defined. Treatment differs from other inflammatory demyelinating CNS diseases such as multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) despite overlapping symptoms. In this review, we summarise recent knowledge for optimal patient management.
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a distinct inflammatory demyelinating disorder of the central nervous system, and its diagnosis is guided by the 2023 International MOGAD Panel criteria. Its clinical spectrum includes optic neuritis, transverse myelitis, acute disseminated ence...
João Vitor Mahler, Marina Vilardo, G. Silva et al.· Frontiers in Neurology· 0 citations
Importance
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disease distinct from multiple sclerosis (MS) and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD). Magnetic resonance imaging (MRI) is central to confirming attacks, defining lesion di...
E. Flanagan, Brenda L. Banwell, Laura Cacciaguerra et al.· JAMA Neurology· 0 citations
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has emerged as a distinct inflammatory demyelinating disorder of the central nervous system. Although relatively rare, growing recognition of this entity has highlighted important differences from multiple sclerosis and neuromyelitis optica spectru...
Kavya Rajanna, G. Sharma· International Journal of Con...· 0 citations
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory demyelinating disorder distinct from multiple sclerosis (MS) and aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD). Seizures are an important but incompletely characterized manifestation. Their reported...
Chun Li, Liang-Liang Hao, Xue-Yan Liu et al.· Frontiers in Immunology· 0 citations
Myelin oligodendrocyte glycoprotein antibody-associated disease is a demyelinating disorder affecting the central nervous system. Autoimmune regulator mutations disrupt central tolerance and cause immunodeficiency and autoimmune manifestations. We report the case of a 49-year-old Asian male with relapsing myelin oligod...
Lin-Ling Wang, Rui-Wen Hu, Lei Chen et al.· Multiple Sclerosis· 1 citation
The clinical patterns of acute attacks and relapses of multiple sclerosis, NMOSD and MOGAD are discussed, including the clinical and para-clinical modalities that are critical for timely recognition and diagnosis, and available evidence regarding treatment selection and responsiveness is presented.
Yu-Jing Li, Wei Jiang, Chao Zhang et al.· Cell Death and Differentiati...· 0 citations
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