TL;DR
Treatment of MOGAD includes management of the acute episode and the use of chronic immunomodulatory therapy to prevent relapses and sequelae and, in selected cases, the use of chronic immunomodulatory therapy to prevent relapses and sequelae.
Overall, strategies to reduce cumulative anti-CD20 exposure represent a promising direction for long-term treatment optimization, although prospective randomized studies are still needed to define the safest and most effective dosing approaches.
Current evidence for acute treatment (high-dose corticosteroids, therapeutic plasma exchange, and intravenous immunoglobulin), the corticosteroid taper, and maintenance immunotherapy are synthesized, with attention to when treatment should be started and when it may reasonably be stopped.
Treatment de-escalation is sometimes necessary because of adverse effects, comorbidities, infections, treatment fatigue, or life circumstances such as pregnancy, but in pregnancy, management requires balancing maternal disease control with fetal safety, with strategies ranging from continuation of selected therapies to...
Antineutrophil cytoplasmic antibody-associated systemic vasculitides (AAV) are a group of severe, potentially fatal autoimmune diseases that include granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis. The introduction of a modern therapeutic strategy based on t...
How fatigue and other patient-reported symptoms, alongside platelet counts, can inform personalized selection among established and emerging targeted therapies among established and emerging targeted therapies is examined.
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in childhood is a rare but severe condition associated with significant morbidity and treatment-related toxicity. Current therapies mainly rely on high-dose glucocorticoids and conventional immunosuppressants, which may cause substantial long-term a...
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