It is suggested that YY1 preserves B cell identity through coordinated regulation of transcriptional and post-transcriptional programs, with YY1-dependent miRNA networks contributing to the maintenance of B cell-associated gene expression and restriction of alternative lineage programs.
It is demonstrated that post-transcriptional regulation of the Profilin 2 (Pfn2) transcript is essential for differentiation of embryonic stem cells into the primary germ layer lineages and revealed the Pfn2 microRNA-IRE regulatory axis as a critical post-transcriptional regulatory node governing the switch from plurip...
Carolyn Sangokoya, Isabella R. Rosso, Rana Ghandehari-Alavijeh et al.· PLoS Genetics· 0 citations
A unified mechanistic framework by which the level of YAP/TAZ activity determines enhancer landscapes that favor either differentiated or progenitor-like cellular states is proposed, providing a potential basis for applications to regenerative medicine and therapeutic interventions.
Ju-Gyeong Kang, Taejun Seol, Younghoon Kim et al.· Cold Spring Harbor Perspecti...· 0 citations
A role for miR-150 deficiency in biasing ectoderm–mesoderm lineage specification in hPSCs is defined and SOX2 is identified as a key downstream node regulated primarily through altered mRNA stability, with additional involvement of an autophagy-associated pathway.
Xing Zhen, Hyebin Koh, Dong-Seok Lee et al.· Signal Transduction and Targ...· 0 citations
Significance Despite the established role of Rbp-Jκ as the master transcriptional regulator of Notch signaling, its cell-intrinsic functions in natural killer (NK) cells remain unknown. In this study, we integrate genetic ablation (Ncr1iCre × Rbp-Jκfl/fl) studies with scRNA-seq, scATAC-seq, bulk ATAC-seq, CUT&Tag, and...
Hongyan Peng, Yao Yang, Yongjie Liu et al.· Proceedings of the National...· 0 citations
Abstract LIN28A is a conserved RNA-binding protein essential for pluripotency, let-7 miRNA regulation, and cellular metabolism. However, the mechanisms controlling its transcriptional activation during early stem cell fate transitions remain poorly defined. Using the Lin28a locus as a model, we identified multiple intr...
It is revealed that transcription of aak-1/AMPK is necessary to silence transcription in quiescent PGCs, and it is validated PGC transcription of aak-1/AMPK, and it is showed that zygotic aak-1/AMPK is required for PGC chromatin hyper-compaction, supporting reproductive success upon recovery.
Jing-Xian Chen, Sharan Surya, R. Chitrakar et al.· bioRxiv· 0 citations
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