TL;DR
Using acetaldehyde and chloroacetaldehyde as substrates, DERA catalyzed the formation of S-4-chloro-3-hydroxybutyraldehyde (S-CHBAL), indicating its potential for application in the biosynthesis of statin intermediates.
The identification of aldo-keto reductase 1C3 (AKR1C3) as the primary target of myxoglucamides in human cells implies that the search for targets of natural products is rewarding even in the absence of an initial phenotypic activity.
Pyridoxal 5'-phosphate (PLP)-dependent aminotransferases play a central role in nucleoside antibiotic biosynthesis, where they catalyze the conversion of ribose-derived aldehyde intermediates into aminonucleosides by introducing critical amino functional groups. Despite their widespread occurrence in the biosynthetic p...
It is demonstrated that GFAT plays an important role in the hexosamine biosynthetic pathway, trophozoite proliferation, and efficient encystation in Entamoeba, and supports its further evaluation as a potential therapeutic target for amebiasis.
BACKGROUND Diabetes mellitus is a major global health concern. DPP-4 (dipeptidyl peptidase-4) inhibitors containing a 2-cyanopyrrolidine scaffold are in clinical use; however, systematic evaluation of amides derived from amino acids adjacent to the N-2 position of GLP-1 (glucagon-like peptide-1) has not been reported....
Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is a hereditary genetic defect which is one of the most prevalent polymorphisms and enzymopathies in humans, affecting approximately 500 million people worldwide. Antimalarial medications, such as primaquine and tafenoquine, have been linked to the hemolysis in the...
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