Electrochemical Biosensors for Circulating Tumor Cells and ctDNA: Emerging Strategies for Precision Oncology.

Translational optical and electrochemical biosensing strategies for liquid biopsy in triple-negative breast Cancer: advances, challenges, and clinical implementation.

Triple-negative breast cancer (TNBC) is a highly aggressive subtype with no specific therapeutic targets and a high risk of early metastases. Liquid biopsy has emerged as a promising method for real-time monitoring using biomarkers like microRNAs, circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and Extra...

RNA biosensors in oncology: Mechanisms, Cancer-specific applications, and a Hallmark-aligned clinical roadmap.

Cancer diagnosis continues to rely on invasive tissue sampling and static molecular assessments that cannot reflect the real time RNA alterations driving tumour progression. RNA biosensors are genetically encoded or synthetic devices that translate specific RNA markers and tumour microenvironment signals into measurabl...

Microfluidics and biosensors-driven detection of exosomes: advances in aptamers, peptides and POC devices for next-generation diagnostics

Recent advances in biosensors for cancer diagnosis and analytical strategies

This review summarizes relevant biosensor types, including electrochemical, optical, mass-sensitive, microfluidic, nano-biosensors (recently developed), and hydrogel-based systems with discussion of their underlying analytical principles and performance for clinically important cancer biomarkers.

Label-Free Electrochemical Biosensors for Triple-Negative Breast Cancer Biomarkers: Emerging Recognition Strategies, Nanomaterials, and Clinical Translation

Triple-negative breast cancer (TNBC) is when the patient does not have the three most targeted molecules (estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 or HER2) and the patient resorts to chemotherapy (cytotoxic), and poor prognosis due to the fact that the three most targeted m...

Fluorosphere-Assisted Nano-Biosensor for Detection of Circulating microRNAs in Non-Small Cell Lung Cancer

Non-small-cell lung cancer (NSCLC) diagnosis is challenged owing to the need for reliable, non-invasive biomarkers. Circulating cell-free microRNAs (ccf-miRNAs) are promising candidates, but their low levels and short sequences in blood complicate detection. In this study, a novel nano-hybrid fluorescent array was deve...