2026· Advances in Cancer Research· Vol 172, pp.
97-162
· 0 citations
Medicine
TL;DR
This chapter provides an integrated framework for understanding TAM biology across multiple regulatory dimensions, including ontogeny, plasticity, metabolism, epigenetic control, and spatial niche organization, and synthesizes current and emerging therapeutic strategies targeting TAM recruitment, survival, reprogramming, and phagocytic function.
Tumor-associated macrophages (TAMs) are abundant and functionally important components of the tumor microenvironment (TME), yet the molecular programs that distinguish pathogenic macrophage states from tissue-adaptive populations remain incompletely defined. Triggering receptor expressed on myeloid cells 2 (TREM2) has...
Xue-Jun Guo, Jing-Ya Yu, Xiao-Yan Lin et al.· Critical reviews in oncology...· 0 citations
Tumor-associated macrophages (TAMs) are critical regulators of the tumor microenvironment. They exhibit diverse pro-tumorigenic and antitumor phenotypes depending on their monocyte-derived or tissue-resident origins. Beyond biochemical signaling, the mechanical properties of the tumor microenvironment, including extrac...
Dayeon Kim, Y. Kim, Jih-Ye Lee et al.· Frontiers in Cell and Develo...· 0 citations
A framework in which metastasis is dynamically codetermined by tumor cell plasticity and host systemic state is described, contextualized by recent mechanistic insights into how lifestyle and physiological states rewire organ microenvironments to become either permissive or restrictive to metastatic colonization is des...
Gwennan Ward, Álvaro Ruiz-Tabas, P. Altea-Manzano· FEBS Letters· 0 citations
Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological dysfunction. This review provides a comprehensive analysis of TRM biology in inflammation and cancer. We first delineate the het...
Si-Yuan Huang, Jiang-Bo Fan, Wen-Yi Liu et al.· MedComm· 0 citations
ABSTRACT Immune‐cell dynamics within the tumor microenvironment (TME) determine whether immune cells can reach, recognize, and sustain antitumor function against malignant cells under suppressive pressure. These dynamics are shaped by hypoxia, nutrient stress, cytokine and chemokine signaling, stromal architecture, vas...
Pin Guo, Yi-Zhao Xie, R. Song et al.· MedComm· 0 citations
The tumor microenvironment (TME) is a dynamic and complex ecosystem in which endothelial cells (ECs) play a central role beyond their traditional function as passive vascular conduits. Increasing evidence indicates that tumor-associated endothelial cells (TECs) undergo profound phenotypic and functional reprogramming,...
G. Rathod, P. Parmar, A. Teja· Vascular Biology· 0 citations
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