It is demonstrated that cell surface sialic acid is essential for EV-D68 to bind to and infect susceptible cells and that virus binding to a sialic acid receptor and to immunoglobulin-like receptors used by most other enteroviruses share a conserved mechanism for priming viral uncoating and facilitating cell entry.
Swine influenza virus (SIV) poses a continuous threat to global pig production and public health. Efficient SIV replication is highly dependent on host factors, making their identification and functional characterization important for the development of host-directed antiviral strategies. Here, we investigated the role...
Hui-Min Sun, Di-Dan Luo, Shao-Yu Tu et al.· Microbiology Research· 0 citations
ABSTRACT African swine fever (ASF), caused by the African swine fever virus (ASFV), remains one of the most devastating transboundary animal diseases worldwide, with case fatality rates reaching up to 100% in acute infections. Viral entry represents the first essential step in infection and is an ideal target for the d...
Jia-Qi Li, Chuan-Xia Liu, Wei-Tao Huang et al.· Journal of Virology· 0 citations
Simplexviruses of non-human primates differ in their capacity to cause severe disease in humans. Papiine alphaherpesvirus 2 (PaHV-2) of baboons has not been reported to be pathogenic in humans while human infection with macacine alphaherpesvirus 1 (McHV-1, Herpes B Virus) can cause fatal disease. In order to study PaHV...
ABSTRACT Measles virus (MeV) is the most contagious human respiratory pathogen. To understand how it spreads in the airways, we infected well-differentiated primary cultures of human airway epithelial cells (HAE). We discovered that the MeV attachment protein (hemagglutinin, H), the fusion (F) protein, and the assembly...
S. Clark, Justin W. Kaufman, Kalpana Yadav et al.· Microbiology spectrum· 0 citations
Enteroviruses are among the most common viral pathogens in humans, causing illnesses ranging from the common cold to severe and sometimes life-threatening diseases such as acute haemorrhagic conjunctivitis or poliomyelitis. To replicate efficiently within host cells, enteroviruses hijack several host factors, including...
Vladimira Horova, Michala Zgarbová, M. Klíma et al.· Antiviral Research· 0 citations
African trypanosomes replicate within the blood and tissue spaces of their mammalian hosts. As extracellular pathogens, they are constantly exposed to immune cells and molecules and are susceptible to killing by components of the complement system. In this study, we conducted a large-scale screen of a panel of human co...
Alex Cook, Helena Webb, Nicola Minshal et al.· bioRxiv· 0 citations
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