TL;DR
It is suggested that severe adolescent depression represents a clinically defined severity stratum associated with neuroimmune alterations in the context of childhood adversity and recent life stress, rather than a discrete biological subtype.
It is hypothesized that individuals with greater childhood maltreatment severity, particularly severity of emotional abuse and neglect, will exhibit stronger DACS, reflecting greater temporal coupling between depression and anxiety symptoms, and whether childhood maltreatment severity and subtype predict stronger coupl...
Non-suicidal self-injury (NSSI) is prevalent among adolescents with depressive disorders, with childhood maltreatment (CM) as a key risk factor. However, how distinct CM types differentially influence NSSI risk in this population remains unclear. Moreover, emotion dysregulation and depressive symptoms have rarely b...
Adolescents with MDD, particularly females, exhibit a high prevalence of comorbid psychotic symptoms, closely associated with CM and depression severity, and these cross-sectional findings highlight significant vulnerability.
The path from childhood abuse to severe depression is characterized by a cognitive-somatic cascade: abuse fuels persistent negative thinking, which exacerbates the perception and burden of physical symptoms, ultimately deepening depressive severity.
ABSTRACT Background: Childhood maltreatment (CM) is associated with an increased risk of mental disorders, with oxidative stress (OS) being proposed as a potential mediator. However, it remains unclear whether exposure to specific types of CM during distinct developmental periods is associated with altered OS levels. O...
A history of CM and impaired sleep quality introduce new stressors in managing one's own illness that have received little attention to date, and the present study found that these factors were at least partly influential on the Fear-of-Relapse Scale.
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