TL;DR
This review, based on current literature, explores the unique properties of MSCs and the latest advancements in the synergistic effects of MSCs and GelMA hydrogels in promoting bone regeneration.
It is suggested that gradient nHA-loaded CMCS hydrogels can effectively enhance osteogenesis and support bone regeneration.
3D-printed polylactic acid scaffolds coated with polydopamine and loaded with CS nanoparticles encapsulating 4-methoxycinnamic acid (MCA), a hydrophobic polyphenolic compound with antioxidant and anti-inflammatory activities offer a robust platform for scaffold-based bone tissue engineering strategies.
Bone defects caused by trauma, infection, tumour resection and impaired healing remain difficult to reconstruct because successful repair requires coordinated mechanical stability, vascularisation, immune regulation and osteogenesis. Natural-based hydrogels provide hydrated, extracellular-matrix-mimicking platforms tha...
Scaffold-based bone tissue engineering (BTE) represents a pivotal strategy in regenerative medicine, offering substantial promise for repairing damaged bone. These scaffolds provide essential structural support and promote new bone formation by mimicking the native extracellular matrix (ECM). The rational design of an...
Articular cartilage repair and regeneration remain challenging due to limited cell infiltration and insufficient chondrogenic differentiation within engineered scaffolds. Although poly(vinyl alcohol) (PVA)-based hydrogels exhibit excellent mechanical stability and structural integrity, their intrinsic bioinertness an...
The central challenge in bone tissue engineering is not merely to fabricate bone-like materials, but to reconstruct a regenerative microenvironment that recapitulates native bone. Decellularized extracellular matrix (dECM) retains tissue-specific structural components and biological cues and is therefore regarded as a...
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