TL;DR
Priorities include diagnostics resolving subpopulation-level resistance, their integration into surveillance frameworks, particularly in low- and middle-income settings, and further evaluation of adjuvant strategies.
An expanded model of drug resistance in tuberculosis is proposed, in which diagnostic delay does not constitute a direct cause of resistance but rather a potential amplifying factor for biological adaptation and evolutionary change occurring before treatment initiation.
Background . Antimicrobial resistance (AMR) has high medical and social significance, as it is shaped by clinical, veterinary, agricultural, and environmental processes, as well as horizontal transfer of mobile genetic elements. Its analysis requires the assessment of individual resistance genes, experimental models...
BACKGROUND Antibiotic heteroresistance (HR) is characterised by the coexistence of susceptible and resistant subpopulations within an apparently isogenic bacterial isolate. Because routine antimicrobial susceptibility testing (AST) primarily assesses the dominant population, HR may escape detection, potentially leading...
Lariocidin, a structurally novel ribosome-targeting lasso peptide with broad-spectrum activity against both Gram-positive and Gram-negative multidrug-resistant pathogens, is presented as an emerging therapeutic scaffold that circumvents resistance mechanisms operating across both bacterial groups.
This critical narrative review evaluates target-based and phenotypic screening as complementary discovery architectures rather than competing doctrines, with emphasis on small-molecule antibacterial discovery and transferable lessons for antimicrobial research.
Background: Antimicrobial resistance (AMR) has emerged as one of the most critical threats to global public health, compromising the effective treatment of bacterial infections and increasing morbidity, mortality, and healthcare costs. Despite extensive research, AMR data remain fragmented across regions, pathogens, an...
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