Intranasal Delivery of Piceatannol-Loaded Liposomes for Glioblastoma Management: Formulation Optimization, In Vitro, Ex Vivo, In Ovo and LC-MS/MS- Based In Vivo Pharmacokinetic and Brain Distribution Assessment

Enhanced Brain Biodistribution of Quercetin and Rutin Co-Loaded Pegylated PLGA Nanoparticles Via Intranasal Delivery for Neuroblastoma Therapy

Mucoadhesive Nanoemulsions for Nose-to-Brain Delivery of Dimethyl Fumarate: Development, Characterization and Proof-of-Concept In Vivo Evaluation

Background: Dimethyl fumarate (DMF) is an approved therapeutic agent for the treatment of multiple sclerosis, known for its anti-inflammatory and neuroprotective properties. However, its oral administration is often accompanied by gastrointestinal side effects, limiting its therapeutic potential. In the present study,...

Development, Optimization, and Evaluation of Chitosan Nanoparticles for Co-Delivery of Rivastigmine and Harmaline via Intranasal Route for Brain Targeting

LPR-1-Mediated targeted intranasal delivery of lentinan-loaded polymeric nanocarriers for GBM therapy via modulation of apoptotic signalling.

AIM To develop and evaluate a lactoferrin (Lf)-functionalized polyethylene glycol (PEG)-grafted chitosan (CS) nanocarriers (NCs) for low-density lipoprotein receptor-related protein-1 (LRP1)-mediated intranasal delivery of lentinan (LNT) to enhance brain targeting and anti-glioblastoma (GBM) efficacy. MATERIALS AND M...

Intranasal Delivery of Solid Lipid Nanoparticles Loaded with Carmustine and Temozolomide for Glioblastoma Treatment in Mice

Glioblastoma multiforme remains one of the most aggressive and lethal central nervous system malignancies, primarily due to the restrictive nature of the blood–brain barrier which severely limits the efficacy of systemically administered chemotherapeutics. To address this critical challenge, this study aims to overcome...

Clove Oil-based Nanoemulsion Co-loaded With Saquinavir, Ritonavir and Acyclovir for Enhanced Oral Pharmacokinetics and Brain Exposure in Herpes Simplex Encephalitis and NeuroAIDS