Aug 2026· European Archives of Psychiatry and Clinical Neuroscience· Vol 276, pp. 3847 - 3855· 0 citations· 55 references
Medicine
TL;DR
This study provides the first cross-tissue proteogenomic evidence that RAB27B is a brain-derived, reproducible candidate protein genetically associated with PPD, and nominate RAB27B and pregnenolone as promising directions for postpartum psychiatric research.
This study reveals that SRA1 is a novel therapeutic target for PPD, which enhances the understanding of its molecular aetiology and the development of therapeutic strategies.
Ming Chen, Qinlin Wei, Hao-Wen Li et al.· npj Mental Health Research· 0 citations
Neurological and psychiatric disorders (NPDs) impose a substantial global burden. Many genetic associations have been reported for a range of NPDs, but the specific genes and proteins underlying susceptibility and their tissue- and cell type-specific manifestations remain poorly understood, hindering the developmen...
Yuanhao Yang, Yuan Zhou, Xin Lin et al.· BMC Psychiatry· 0 citations
Background: Cellular heterogeneity limits causal inference in complex diseases. We applied an established cell-type-stratified Mendelian randomization (csMR) framework, originally developed by Hao et al. (2024), to investigate whether lipid phenotypes affect kidney disease through distinct brain cell populations, exten...
This comprehensive genome-wide association meta-analysis revealed new OA-related variants and several blood proteins with possible causal relationships with OA that can contribute to a deeper understanding of the genetic basis of this disease and suggest OA-related pathways as promising targets for further therapeutic...
Qi-Wang He, Yue Liu, Xi-Ming Liu et al.· International Immunopharmaco...· 0 citations
Combining MR, multi-omics and pharmacological evidence, ADM and CFH were prioritized as OA candidate genes and both genes exhibited favorable classification efficacy in these models.
Hao-Yang Li, Dong-Liang Gong, Jun Yang et al.· Biomedicines· 0 citations
This study identified PARP1, SDCCAG8, FST, FOLH1, and NCAN as genetically prioritized candidate proteins for CA, with PARP1 showing the most consistent evidence across analyses.
Da Gao, Hai-Yan Lin, Sheng-Jie Wang et al.· Cardiovascular Therapeutics· 0 citations
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