TL;DR
It is concluded that TSHR is expressed in a subpopulation of folliculo-stellate cells in thee human anterior pituitary, suggesting ultra-short loop regulation of thyrotropin secretion.
Glycoprotein hormone receptors are G-protein-coupled receptors essential for endocrine signaling. Thyroid-stimulating hormone receptor (TSHR), originally expressed in the thyroid gland, has been increasingly detected in various normal and malignant tissues, suggesting a wide range of functions. We hypothesized that ext...
Gastrin-releasing peptide (GRP) is a neuropeptide with diverse physiological functions in mammals. Similar to its mammalian counterparts, chicken GRP (cGRP) is expressed in endocrine cells of the gastrointestinal tract, including the proventriculus, where it regulates gastric acid secretion. Our previous study showed...
The pituitary gland is a key regulator of mammalian reproduction. By secreting the gonadotropins—follicle‐stimulating hormone (FSH) and luteinizing hormone (LH)—the anterior pituitary precisely coordinates reproductive function. The hypothalamus releases gonadotropin‐releasing hormone (GnRH), which in turn regulates th...
This study aimed to examine the expression of follicle stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHR) in the testes of male fattening pigs based on the timing of the first immunocastration dose. A total of 24 male pigs were randomly assigned to 3 groups: C (n=8) consisted of only intact pigs...
The NR4A nuclear receptor family (NR4A1, NR4A2, and NR4A3) comprises stimulus-responsive orphan nuclear receptors expressed in endocrine tissues, including the anterior pituitary gland. However, their functional roles in lactotrophs remain poorly understood. Because prolactin (PRL) secretion varies markedly across repr...
Thyrotropin-releasing hormone (TRH) is classically recognized for its role in regulating the hypothalamic-pituitary-thyroid (HPT) axis; however, it also functions as a central neuromodulator influencing arousal, locomotion, and autonomic processes. Despite these established roles, the circuit-level mechanisms through w...
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