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Multimodal prediction of MCI-to-dementia conversion over a two-year window.

Bipul Simkhada T. Y. Liang Xue-Ting Cui Micheal Adeyosoye Bibhu Simkhada M. Cabrerizo R. C. Cid S. Burke A. Barreto N. Rishe D. Loewenstein M. Adjouadi
Sep 2026 · GeroScience · 1 citation · ⚡ 1 influential · 37 references
Medicine

TL;DR

An explainable multimodal machine-learning framework to predict progression from MCI to dementia within a clinically meaningful two-year period is developed and the convergence of cognitive impairment and region-specific neurodegeneration emerged as the strongest indicator of conversion risk.

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