Sleep quality partially mediates the association between remnant cholesterol inflammatory index and depressive symptoms: multi-cohort analysis from cross-sectional and longitudinal cohorts.

TL;DR

Evidence linking metabolic inflammation, as reflected by RCII, with both depressive symptoms and poor sleep quality is provided, and the identification of sleep quality as a partial mediator suggests that sleep disturbance may represent a potential pathway underlying the association between metabolic dysregulation and depression.