Discovery of Novel Antimicrobial Peptides from Casein via Integrated In Silico and Experimental Approaches: Identification and Mechanistic Insights

The Activity of Antimicrobial Peptides (AMPs) Identified Via an Integrated in Silico and Pilot in Vitro Screening Approach Towards ESKAPE Pathogens.

A stability-centric computational discovery pipeline to identify and characterize novel antimicrobial peptides with potent and selective bactericidal activity against ESKAPE pathogens and to validate the lead candidates through experimental in vitro assays provided a generally applicable strategy for accelerating the d...

Purification, Characterization, and In Vitro Safety Assessment of the Antimicrobial Peptide SAM-KB40 from Bacillus licheniformis SAM-D318.

While the peptide shows promising in vitro dual antibacterial and toxin-neutralizing capacity, its high sensitivity to proteinase K limits oral application.

In Vitro Screening of Short Synthetic Antimicrobial Peptides Toward Food-Relevant Microorganisms: Antifungal Activity and Molecular Docking Analysis

Food spoilage and foodborne microorganisms remain major challenges for food safety and preservation, stimulating the search for alternative antimicrobial agents compatible with minimally processed and clean-label products. In this study, six short synthetic peptides containing arginine, or both lysine and arginine resi...

In silico design and In Vitro validation of WK15: a promising antimicrobial peptide for aquaculture applications

Development of Novel Antimicrobial Peptides and Their Engineering into Nanoparticles to Improve Performance

This study identified potent AMPs with promising therapeutic potential by constructing and screening a synthetic random peptide library using a bacterial surface display system, and identified WP-4 and WP-6, which showed high antimicrobial activity, good biocompatibility, rapid bactericidal effects, and low propensity...

Rational Design and In Silico Evaluation of a Dual-Action Antimicrobial Peptide Targeting Efflux Pump and Membrane Integrity in Pseudomonas aeruginosa.

2ANN is identified as a promising AMP candidate for further investigation against MDR P. aeruginosa, as the findings are based exclusively on computational prediction and simulation, experimental validation is required to confirm its biological activity and mechanism of action.