Prespecified analysis plan — voxel-level recovery of the oxygen-transfer constant from exported DSC-MRI capillary-function maps, and its calibration anchor
Abstract
Prespecified analysis plan (version 2.0, 21 September 2026) for a methods study of maps exported by a commercial DSC-MRI capillary-function software package. The study tests whether the exported model-based maximum oxygen extraction fraction (OEFmax) map is reproduced voxel by voxel by a published closed-form limiting case of the Jespersen–Østergaard capillary oxygen-extraction model with a single oxygen-transfer rate constant; recovers that constant from the exported maps alone; bounds the reconstruction residual; and identifies the transit-time state at which the constant returns the published calibration target. Secondary analyses address export-side interpolation and the directional curvature of the model along adjacent voxel pairs. Data: 122 patients with untreated IDH-wildtype glioblastoma, the paired-analysable set of a companion study whose feature data are public (doi:10.5281/zenodo.21908596). Native vendor-export grid. No clinical outcome data are used. Status at deposit: deposited before the extraction of voxel-level data. Exploratory analyses carried out earlier on compartment medians are listed with their dates in section 2 of the plan. Files:- Analysis_plan_k_recovery_v2_0_2026-09-21.md — the analysis plan- k_recovery_voxel.py — analysis script, SHA-256 1fcb5c54cbe599e16c0731c5869b18534502ef00ac91c78c294710cc9b8bad71- extract_voxels_export_grid.py — extraction script, SHA-256 edb3949e65653d385192c302b2915894b5e9ba55b421891ef2f15bf1710a18ce Later changes will be recorded as dated amendments in new versions of this record. Results will be deposited in a separate, linked record. Files are restricted until publication of the associated article. The software manufacturer has no role in the design, conduct, analysis or reporting of this study.
