TL;DR
Findings identify endothelial TRIM47 as a potential therapeutic target for BBB repair and neurovascular recovery and AAV-mediated Trim47 knockdown restored vascular integrity and improved outcomes after ICH.
ABSTRACT Extracellular vesicles (EVs) are essential for intercellular communication and significantly influence neuroimmune responses after intracerebral haemorrhage (ICH). This study elucidates the immune mechanisms underlying secondary brain injury following ICH by identifying microglia‐derived migrasomes. By integra...
Efficient clearance of myelin debris is essential for white matter repair in vascular cognitive impairment (VCI) caused by chronic cerebral hypoperfusion, but the underlying cell-specific mechanisms remain poorly defined. Here, we investigated the role of astrocytic Caveolin-1 (Cav-1) in regulating this process....
CD147 exacerbates ischemic brain injury and BBB disruption by suppressing neuronal Wnt/β-catenin signaling through a mechanism involving the AKT/GSK3β node, supporting further evaluation of CD147-directed interventions after stroke.
Background Blood–brain barrier (BBB) disruption is a hallmark of acute traumatic brain injury (TBI), yet the immune–vascular mechanisms underlying endothelial dysfunction remain incompletely understood. Perivascular macrophages (PVMs) are strategically positioned to modulate cerebrovascular homeostasis, but their role...
Blood-brain barrier (BBB) disruption correlates with lesion burden and cognitive dysfunction in cerebral small vessel disease (CSVD). Laminin, highly produced by pericytes in the brain, maintains BBB integrity. However, it remains unclear if laminin dysregulation contributes to the pathogenesis of CSVD. Here, we show t...
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