Aug 2026· International Journal of Biological Macromolecules· Vol 379, pp.
154028
· 0 citations· 49 references
Medicine
TL;DR
This study improves the moisturizing, air permeability, antibacterial and healing promoting functions of the hydrogel, providing a new idea for the development of multi-functional wound dressings.
Abstract
The development of hydrogel dressings that exhibit excellent moisturizing, antibacterial, and pro-healing properties is an urgent need in the field of wound healing. This study designs a multifunctional hydrogel dressing (QCPVA-ZnO) to address this challenge by incorporating a quaternized nanocellulose‑zinc oxide hybrid (QCNC-ZnO) into a polyvinyl alcohol/chitosan matrix. QCPVA-ZnO exhibited excellent moisture retention and breathability, with a water vapor transmission rate of 2440 g·m-2·day-1 and an oxygen permeability rate of 111 g·mm/m2·day·kPa, which could be attributed to the synergistic effect of its porous structure and hydrophilic cross-linked network. The experiment of the full-thickness skin defect model in mice showed that QCPVA-ZnO had significant healing promoting ability, with a wound healing rate of 97.6% by day 11. This can be attributed to QCNC-ZnO endowing QCPVA-ZnO with a good bactericidal rate of 99%, which thereby enabled the latter to effectively control infections, reduce inflammatory reactions, and further promote angiogenesis and epidermal regeneration. In addition, biosafety evaluations indicated that QCPVA-ZnO had a cell survival rate of over 90% and hemolysis of less than 2%, demonstrating good biocompatibility. This study improves the moisturizing, air permeability, antibacterial and healing promoting functions of the hydrogel, providing a new idea for the development of multi-functional wound dressings.
Stable hydrogel formation with favorable porous architecture, swelling behavior, thermal stability, and homogeneous distribution of nanovesicles was well established and exhibited excellent biocompatibility, hemocompatibility, and enhanced cell-material interactions.
Rizos Evangelos Bikiaris, Ioanna Koumentakou, A. Niti et al.· ACS Applied Bio Materials· 0 citations
It is demonstrated that the catechol-nanocellulose/chitosan polymeric hydrogel effectively overcomes adhesion, infection, and oxidative stress barriers in diabetic wound healing, making it a promising candidate for difficult-to-heal chronic ulcers.
The self-adaptive sprayable hydrogel dressing developed in this work integrates rapid molding, broad-spectrum antibacterial, antioxidant, and healing-promoting functions, offering a promising new strategy for the effective treatment of complex clinical wounds.
Jinyu Shan, Xinru Wang, Jie Zhang et al.· International Journal of Bio...· 0 citations
This work presents a mechanically robust, highly efficient, and exceptionally safe light-activated platform for advanced wound dressing applications and demonstrates strict biosafety without collateral phototoxicity.
Wound healing remains a formidable biomedical challenge, often complicated by infection, dehydration, and delayed tissue regeneration. To address these challenges, a novel bio-composite hydrogel was synthesized, via a simple solution-casting method, using carboxymethyl starch, polyvinyl alcohol, and citric acid. The hydrogel was enriched with biogenic nano-zinc oxide (nZnO) and Aloe vera extract, both derived by green synthesis, using Citrus maxima peel and methanol, respectively. Structural integrity and functional performance of the hydrogel were characterised, using FTIR, XRD, FESEM, and antibacterial assays. The prepared bio-composite hydrogel exhibited excellent swelling (350%), gel fraction (81.35%), porosity (62%) and WVRT (2380 g/m2day), with tensile strength reaching 28.64 MPa, ensuring durability of the membrane. The incorporation of biogenic nZnO into the hydrogel produced strong antibacterial activity (ZOI: 28 mm for S. aureus, 21 mm for E. coli), while Aloe vera enhanced the flexibility and healing efficiency of the hydrogel. Cytotoxicity assays confirmed excellent cytocompatibility (>96% cell viability) with negligible hemolytic activity, while antioxidant evaluation showed 64.52% DPPH radical scavenging at 25 μg/mL. In vivo studies using a murine excision wound model revealed rapid wound healing, achieving 98% closure by day 12, accompanied by enhanced re-epithelialization and deposition of collagen. These results suggest that the developed bio-composite hydrogel membrane holds significant promise as a wound dressing material for effective wound management.
M. H. Mondal, H. J. Kadri, Firoz Ahmed· International Journal of Bio...· 0 citations
A polyacrylic acid/polyvinyl alcohol composite hydrogel fabricated via self‐catalyzed free radical polymerization, with borax serving as the reinforcing phase, achieves synergistic antibacterial and intelligent responsive therapeutic performances, providing a reliable and high‐efficiency candidate for advanced wound care and next‐generation wound dressing applications.
Lin-Han Hu, Zheng Yang, Xin-Wei Tao et al.· Macromolecular Bioscience· 0 citations
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