Explorative review on Bauhinia acuminata L.: Bioactive phytoconstituents and therapeutic efficiency

Abstract

Bauhinia acuminata L., belonging to the family Fabaceae, has been traditionally employed in various indigenous medicinal practices of the Indian subcontinent. Despite its long-standing therapeutic use, systematic scientific evaluation of its bioactive potential has remained limited. The present review discussed and analyzed experimental findings related to the phytochemical constituents and pharmacological activities of this species. Phytochemical screening of different plant parts revealed the occurrence of biologically active compounds such as alkaloids, flavonoids, glycosides, phenolic compounds, saponins, and tannins. Investigations conducted using in vitro methods and in vivo models demonstrated notable antimicrobial, anti-inflammatory, analgesic, anthelmintic, antioxidant, antidiabetic, cytotoxic, and hemolytic properties. Extracts derived particularly from the stem bark and leaves showed appreciable biological activity. Furthermore, experimental studies reported protective effects against chronic arsenic-induced toxicity, suggesting its prospective role in mitigating oxidative and cellular damage. The observed pharmacological responses were correlated with availability of plant’s rich phenolic and flavonoid content, which contributed to free radical scavenging and protective actions. Although the available findings supported many of its traditional claims, inconsistencies in extraction procedures and study designs highlighted the necessity for further controlled investigations. Standardization of dosage, identification of active principles, safety profiling, and clarification of mechanisms of action were required to advance its therapeutic application. Overall, the compiled evidence indicated that Bauhinia acuminata represented a promising candidate for development of future plant-based medicinal agents.