Sep 2026· Journal of Bioenergetics and Biomembranes· Vol 58· 0 citations· 46 references
Medicine
TL;DR
Targeting the FTO-GPX4 axis may offer novel therapeutic strategies for ALI, and silencing FTO in vivo significantly ameliorates pulmonary tissue pathology, impaired lung function, ferroptosis, and inflammatory responses in mice, whereas GPX4 inhibition reverses this protective effect.
Introduction Acute lung injury (ALI) is a severe inflammatory syndrome characterized by disruption of the alveolar-capillary barrier, pulmonary edema, and impaired gas exchange. Ferroptosis has emerged as an important contributor to ALI pathogenesis, but the mechanisms associated with reduced glutathione peroxidase 4 (...
Xiao-Yun Guo, Wei-Feng Yan, Wen-Yong Peng et al.· Frontiers in Cell and Develo...· 0 citations
A novel SIRT2/IER3-mediated mechanism driving ferroptosis in AP is revealed, and serum SIRT2 and IER3 were elevated in AP patients and correlated with disease severity and inflammation.
Shi-Ya Ma, Zhao-Jian Shen, Chong-Zhi Zhu et al.· Cellular and Molecular Gastr...· 0 citations
Findings indicate that ferroptosis and oxidative stress are pivotal in SIDD, and AC was demonstrated to potentially alleviate SIDD by regulating the PI3K/AKT/NRF2 pathway.
Findings indicate that 4-OI alleviates TAA-induced acute liver injury, at least in part, through activation of the Nrf2/HO-1 signaling pathway and suppression of pyroptotic activation and mitochondrial dysfunction-associated inflammatory amplification.
Liang-Hong Lv, Wen-Chang Yang, Qian Yu et al.· Frontiers in Pharmacology· 0 citations
Background Sepsis-induced acute lung injury (ALI) remains a devastating complication of sepsis, marked by uncontrolled pulmonary inflammation, alveolar-capillary barrier disruption, and high mortality. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, is implicated in sepsis-rela...
Jin Li, Ya-Zhou Li, Chun-Tao Song et al.· Frontiers in Immunology· 0 citations
Acute lung injury (ALI) is characterized excessive inflammatory signaling and uncontrolled cytokine production. Tristetraprolin (TTP) is a key post-transcriptional regulator of inflammatory cytokines that negatively regulates inflammatory pathways. PP2A emerges as an important player to activate TTP. However, wheth...
Yong-Hong Zhang, Shao-Bo Hu, De-Xin Zhang et al.· Archives of Medical Science· 0 citations
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