11-Oxo-mogroside V attenuates lung adenocarcinoma progression by disrupting metabolic homeostasis and suppressing TGFβ2/Myc-dependent oncogenic signaling

Abstract

Highlights • 11-oxo-mogroside V suppresses LUAD progression in vitro and in vivo.• It disrupts metabolic homeostasis by reducing ATP, glucose, and LDH.• The compound induces G0/G1 arrest and promotes apoptosis in cancer cells.• It directly targets TGFβ2, HDAC1, and c-Myc to block oncogenic signaling.• Multi-pathway intervention positions it as a promising LUAD therapeutic.