Skip to content
Open access

Peroneutone A, a new highly oxygenated diterpenoid with diverse biological activities from Peroneutypa scoparia

· Records of Natural Products · 0 citations

TL;DR

Compounds 1–4 showed antifungal and anti-inflammatory activities, and 1 exhibited the strongest inhibition against Candida albicans together with selective cytotoxicity toward A549 cells, expanding the chemical and biological diversity of pimarane diterpenoids from P. scoparia.

Abstract

A chemical investigation of the endophytic fungus Peroneutypa scoparia RJHH-3 led to the isolation of a new highly oxygenated pimarane diterpenoid, peroneutone A (1), together with three known analogues, scopararane C (2), libertellenone A (3), and 9α-hydroxyisopimara-8(14),15-dien-7-one (4). The structure of 1 was established by HRESIMS and extensive NMR analyses, while its stereochemistry was determined by NOESY, NMR calculations, DP4+ analysis, and ECD calculations. Compounds 1–4 showed antifungal and anti-inflammatory activities, and 1 exhibited the strongest inhibition against Candida albicans (MIC = 0.6 μM) together with selective cytotoxicity toward A549 cells (IC50 = 6.9 μM). These findings expand the chemical and biological diversity of pimarane diterpenoids from P. scoparia.

Read PDF

Similar papers

Open access Sep 2026

Discovery and Semisynthesis of Arthritacins A–J—Terpestacin-Derived Sesterterpenoids from the Plant Endophytic Fungus Arthrinium sp. HS66

Ten undescribed terpestacin-type sesterterpenoids, arthritacins A–J, together with five known analogues, together with five known analogues (11–15), were obtained from the endophytic fungus Arthrinium sp.

Xiao-Zheng Su, Kun Hu, Xing-Ren Li et al. · 0 citations
Sep 2026

Smilaxsieboldiol A, a new stilbenoid from the whole plants of Smilax sieboldii Miq. (Smilacaceae).

As part of an ongoing search for new anti-adipogenic agents from medicinal plants, a new stilbenoid (6), together with eight known compounds (1-5 and 7-9), was isolated from the whole plants of Smilax sieboldii Miq. (Smilacaceae). The structure of smilaxsieboldiol A (6) was elucidated using spectroscopic and spectromet...

Ye-On-Woo Jung, Jung A. Lee, Yun-Hyeok Choi et al. · 0 citations
Open access Aug 2026

New Prenylated Isoindolinone Alkaloids and Polyketides from the Mangrove-Derived Fungus Aspergillus sp. SCSIO 41440

New prenylated isoindolinone alkaloids, aspernidines C-E (1–3), a new diketopiperazine alkaloid, protubonine C (4), and new polyketides, (±)-asperisocoumarin J and asperisocoumarin K (5 and 6), were isolated from the mangrove-derived fungus Aspergillus sp. SCSIO 41440, together with six known compounds (7–12). Comprehe...

Chun Yang, Yi Chen, Zhi-Fei Xiong et al. · 0 citations
Aug 2026

Euphiquorins A-E, five new structurally diverse diterpenoids from Euphorbia antiquorum L.

Phytochemical investigation of the whole plant of Euphorbia antiquorum led to the isolation of sixteen diterpenoids, including five new compounds, euphiquorins A-E (1, 5-8), together with eleven known analogues (2-4, 9-16), which were elucidated by comprehensive spectroscopic analyses and quantum chemical calculations.

Yuan-Lin Kong, Wei-Tao Yang, Ji-Lin Zhou et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.