Aug 2026· Journal of Molecular Neuroscience· Vol 76· 0 citations· 39 references
Medicine
TL;DR
An integrative transcriptomic and proteomic Mendelian randomization study incorporating expression quantitative trait loci (eQTL) and protein quantitative trait loci (pQTL) datasets to prioritize genes associated with MDD prioritize CKAP2 as a candidate gene with convergent but non-confirmatory genetic evidence for involvement in MDD.
This integrative multi-omics study identified HSPE1 as a candidate BD risk gene with immune-cell-related regulatory evidence, providing insight into BD pathogenesis and supporting functional validation.
Peng Shen, Hao-Hao Xu, Yan Zhou et al.· European Archives of Psychia...· 0 citations
Aims: To characterize transcriptomic alterations associated with major depressive disorder (MDD) in postmortem human brain tissue and integrate differential gene-expression findings with protein-protein interaction, functional-enrichment, and drug-gene interaction analyses.
Study Design: Exploratory in silico transcri...
Laura Gomes Libório, Sophia Massesine Pimentel, Sara Laíse Cordeiro· Journal of Advances in Medic...· 0 citations
Neurological and psychiatric disorders (NPDs) impose a substantial global burden. Many genetic associations have been reported for a range of NPDs, but the specific genes and proteins underlying susceptibility and their tissue- and cell type-specific manifestations remain poorly understood, hindering the developmen...
Yuanhao Yang, Yuan Zhou, Xin Lin et al.· BMC Psychiatry· 0 citations
It is suggested that CD4 may represent a promising immune-related candidate signature associated with the co-occurrence of FH and MDD, warranting further functional validation.
Chen-Xi Liu, Yu-Ting Li, Xiang Cao et al.· International Journal of Mol...· 0 citations
This study systematically delineates a genetically supported regulatory network of immune cell-specific gene expression in bipolar disorder, predominantly implicating CD8⁺ effector T cells, plasma cells, and B cells, thereby providing a genetic framework for prioritizing candidate targets for future investigation.
X. Mo, Dong-Ren Sun, Fang-Fang Li et al.· Psychiatry Research· 0 citations
These findings connect MDD polygenic risk to motor-cortical inhibitory-neuron biology and experimentally tractable circuit mechanisms and provide scDepBrain as a resource for exploring MDD-associated cellular programs across the brain.
Y. Ma, H. Han, C. Chen et al.· medRxiv· 0 citations
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