Royal Netherlands

Visual deprivation in adulthood engages presynaptic plasticity of thalamocortical synapses

It is shown that robust and reversible plasticity can be induced in adult mice by prolonged dark exposure (DE) and light reintroduction (LRx) and that robust plasticity is engaged at thalamocortical synapses in adults by visual deprivation, a non-invasive manipulation with therapeutic potential.

Selective vulnerability of intracortical projection neurons drives long-term cortical circuit rewiring after perinatal hypoxia

Cortical circuits are built at perinatal times and gradually refined in an activity-dependent manner during a so-called postnatal period of critical plasticity. Although lesions of the central nervous system (CNS) happening during this period typically recover better than those occurring later in life, they are often a...

Network integration of neocortical Cajal-Retzius neurons shapes early cortical dynamics and contributes to their transient nature

Cajal-Retzius neurons (CRN) represent an early-born transient neuronal population in the mammalian neocortex. They are best known for secreting reelin, which is essential for neuronal migration and layer formation in the developing cortex. However, their functional integration into developing cortical circuits and thei...

Bassoon is required for adult mouse ocular dominance plasticity and experience-induced changes in synapsin phosphorylation in visual cortex

Lateralized Tenm4 expression biases visual performance and modulates axonal growth and pre-synapse size in retinal ganglion cells

The precise wiring of neuronal connections is a striking feature of the central nervous system and is critical for correct brain function. During vertebrate visual development, retinal ganglion cells (RGCs) establish synaptic connections with postsynaptic cells in the optic tectum, a process that is in part conferred b...

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