Review

REVIEW ARTICLE Alzheimer’s disease: genetic background in the era of next-generation sequencing technologies

L. Lukyova A. Zaťková J. Minarík Zuzana Holesova J. Budiš M. Kucharík Vladimír Beneš Juraj Gazdarica T. Szemeš

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TL;DR

This review synthesizes current understanding of the genetic architecture of Alzheimer’s disease in the era of next-generation sequencing, with particular emphasis on variant classes beyond single nucleotide polymorphisms, and discusses somatic mosaicism that represents another layer of its complexity.

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