Findings support a role for USGs in the genetic architecture of SZ and suggest that common variation within this system may link genetic susceptibility to neurodevelopmental processes and cognitive heterogeneity in SZ.
A high-resolution cellular and temporal framework of SZ susceptibility is established, implicating mature associative IT microcircuits, deep-layer thalamocortical-regulating networks, and early developmental specification windows as primary points of genetic convergence in SZ.
Yong Wu, Yuan Gao, Miao Li et al.· Molecular Psychiatry· 0 citations
A systematic consolidation of current evidence supporting the involvement of CNNM2 in SCZ pathogenesis provides a direction for further investigation of the pathological mechanisms underlying this disease, and for identification of novel targets for clinical intervention.
Yang Jin, Li-Ge Zhang, Xiaoyi Yao et al.· Neuroscience· 0 citations
Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited1,2. Here, to gain deeper insights into the aetiology of different brain diseases, we used specimens f...
Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse et al.· Nature· 6 citations
A reorganization of molecular networks in schizophrenia is demonstrated, with alterations in the micro-architecture of molecular couplings, strengthening the importance of investigating functional interactions among molecules, as such analyses may reveal significant alterations in schizophrenia that cannot be detected...
G. De Simone, T. Nuzzo, A. di Maio et al.· International Journal of Neu...· 0 citations
Background Autism polygenic scores (PGS) reliably predict case–control status yet explain little variance in autism-related traits. Landscape accounts of neurodevelopmental diversity propose that genetic liability broadens the range of viable neural configurations rather than shifting brain organisation toward dysfunct...
J. Bathelt, Danae Mitsea, Hilde M. Geurts· bioRxiv· 0 citations
These findings provide a cell-type-resolved and ancestry-aware atlas of genetically regulated expression in the human prefrontal cortex and illustrate how single-nucleus transcriptomics can sharpen gene discovery and therapeutic target prioritization for complex brain disorders.
S. Venkatesh, Roman Kosoy, Zhen-Yi Wu et al.· Nature· 7 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.