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Targeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma

Kelsey Keith Min Peng Cristina Remes Victoria Miranda Nicholas A. Wachowski M. Kose S. Dharaskar S. Haroon Agustin B. Velasco Priya Sivaramakrishnan Donna M. Iadarola Sundeep Dugar Marni J. Falk
Jul 2026 · bioRxiv · 0 citations · 57 references
Medicine Biology

TL;DR

Combination therapies targeting multiple of these glucose signaling pathway proteins, together with glucose and N-acetylcysteine, yielded superior therapeutic benefit in complex I disease cell and C. elegans models.

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