It is hypothesized that p.T8I disrupts NAc ACh dynamics and affects social avoidance following social defeat and promotes selective social avoidance toward aggressors and elevated anxiety after CSDS, highlighting a potential cholinergic mechanism underlying stress-induced social avoidance with broader relevance to psychiatric disorders.
BACKGROUND
Depression and substance use disorders frequently co-occur, yet it remains unclear whether similar depression-related behaviors reflect a common underlying neural state. Cocaine use is associated with worsening depressive symptoms, suggesting that drug exposure may interact with pre-existing behavioral state...
Yoko H. Ohnishi, Yoshinori N. Ohnishi, Y. Kawahara et al.· Progress in Neuro-psychophar...· 0 citations
The role of microglial engulfment of D1rs in mediating behavioral consequences of SI is tested using neutrophil inhibitory factor (NIF) to block complement-mediated engulfment required for D1r pruning, and sex specific impacts of SI on brain development and the DA system are found.
Madeline Clark, Emily Gershowitz, Ben Devlin et al.· bioRxiv· 0 citations
Rats with region-specific OXTR knockdown failed to establish socially-conditioned place preference, suggesting OXTRs within the VTA, NAc, and LS are independently needed to drive the reinforcing effect of social interaction.
Julia Stall, Kah-Chung Leong· Pharmacology, Biochemistry a...· 0 citations
Brain monoamine systems regulate a wide spectrum of behaviors. Serotonin (5-HT) is traditionally linked to depression, whereas dopamine (DA) is associated with anhedonia and impaired motivation. The genes for the 5-HT1A receptor (Htr1a) and DRD2 receptor (Drd2) share a common transcription factor, Freud-1, encoded by C...
E. Kondaurova, Yulia D. Grygoreva, D. Eremin et al.· Behavioural Brain Research· 0 citations
It is demonstrated that psilocybin exerts domain-specific, enduring effects on social cognition in an established model of compulsive-like behavior, potentially involving prefrontal plasticity-related mechanisms.
J. Gattuso, B. Bezcioglu, J. Hendey et al.· Molecular Psychiatry· 0 citations
These findings suggest that NAcc D2-MSNs are recruited under conditions of environmental novelty to modulate feeding-related decision-making, and may impair behavioral flexibility and contribute to maladaptive feeding patterns, with implications for the neurobiology of eating disorders.
A. S. V. van Irsen, Tess Kool, Salimat Semenova et al.· Journal of Neuroscience· 0 citations
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