TL;DR
This chapter offers a comprehensive, reproducible protocol for identifying and clinically validating circulating long noncoding RNA (lncRNA) biomarkers for NAFLD and NASH.
Background The fecal lipidomic changes underlying the colorectal adenoma-carcinoma sequence remain incompletely characterized, particularly regarding the continuous metabolic trajectory and heterogeneity of precancerous adenomas. We aimed to use publicly available multi-omics data and an integrative computational frame...
Background: Fibrosis development in patients with metabolic dysfunction–associated steatotic liver disease (MASLD) is a key indicator of disease progression and clinical outcome. Bulk and single-cell transcriptomics on human tissue have advanced understanding of fibrosis progression, but interstudy heterogeneity and li...
These findings bridge the gap between metabolic lipotoxicity and epigenetic regulation, suggesting that lactylation acts as a critical driver in NAFLD pathogenesis.
Metabolic dysfunction-associated steatotic liver disease (MASLD), the leading cause of chronic liver pathologies worldwide, represents a growing clinical burden. Its diagnosis remains reliant on liver biopsy that limits early detection and the ability to capture molecular changes across disease progression. A systemati...
OBJECTIVE As global smoking rates decline, Lung Cancer in Never-Smokers (LCINS) has emerged as a distinct and increasingly important clinical entity. However, its underlying pathogenesis remains poorly understood, highlighting the need to identify circulating molecular determinants and candidate biomarkers. METHODS G...
Nephrolithiasis and obesity are common and recurrent public health problems, yet current obesity-based risk assessment does not identify which individuals are most susceptible to stone formation. We sought circulating markers linked to obesity-related stone susceptibility and risk heterogeneity rather than a diagnost...
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