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#protein folding Sep 2026

Engineering carboxyl methyltransferase for high-efficiency biosynthesis of methyl salicylate in Escherichia coli.

Methyl salicylate (MeSA) is a volatile methylated aromatic ester widely used in agriculture, food, and pharmaceuticals. Microbial biosynthesis offers a sustainable alternative to plant extraction and petrochemical synthesis; however, efficient MeSA production remains limited by the low catalytic efficiency of carboxyl...

Yuan Gao, Shi-Bo Guo, Jun Wu et al. · 0 citations
Sep 2026

Key enzyme optimization and multi-node metabolic flux regulation drive l-arginine production in Escherichia coli.

Microbial production of l-arginine is often constrained by tight metabolic regulation and insufficient precursor supply. Here a plasmid-free, non-auxotrophic Escherichia coli strain for high-level production of l-arginine was rationally engineered, based on our previous constructed strain G0 with 12.4 g/L l-arginine pr...

Xin Gao, An-Yi Wu, Zi-Teng Yang et al. · 0 citations
Sep 2026

Reconstruction and metabolic regulation of O-succinyl-L-homoserine biosynthesis pathway in Escherichia coli W3110.

The plasmid-free system constructed in this study effectively avoids the plasmid-induced metabolic burden and genetic instability and demonstrates the prominent advantages and great application potential of plasmid-free modular engineering for the efficient biosynthesis of OSH and other high-value amino acids.

Si-Min Huang, Xu-Yue He, Ruo-Nan Wang et al. · 0 citations
Sep 2026

Efficient Production of Vanillyl Alcohol in Escherichia coli via Protein and Pathway Engineering

Vanillyl alcohol (VNA) is a high-value compound used in the pharmaceutical industry and other fields. Its microbial de novo biosynthesis is severely limited by the low catalytic efficiency of O-methyltransferase. Here, we constructed a V314I mutant of caffeate O-methyltransferase via structure-guided protein engineer...

Jin-Yi Li, Yong Du, Jia Wang et al. · 0 citations
Sep 2026

Rational design of heptaprenyl diphosphate synthase and metabolic optimization drive biosynthesis of menaquinone-7 by Escherichia coli.

Menaquinone-7 (MK-7) is a fat-soluble vitamin with important nutritional and pharmaceutical applications. However, microbial biosynthesis of MK-7 is limited by low catalytic efficiency of key enzymes, insufficient precursor supply, and imbalanced availability of nicotinamide adenine dinucleotide phosphate (NADPH). In t...

Zi-Hao Li, Kang-Jie Xu, Yi-Yi Chen et al. · 0 citations

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