Uncovering bioactive metabolites from the Taxus wallichiana endophyte Annulohypoxylon purpureonitens using reverse metabolomics

Untargeted Metabolomics and Bioactivity Screening of Mycelial Culture Extracts from Marasmioid Fungi

Huperzia serrata Thallus as a Host-Derived Elicitor Enhances Alkaloid and Terpenoid Biosynthesis in a Sporothrix Endophyte: Insights from Multi-Omics

Endophytic fungi from Huperzia serrata (H. serrata) are promising sources for exploring novel acetylcholinesterase (AChE) inhibitors. In this study, 111 endophytic fungal strains were isolated from wild H. serrata, of which 18 exhibited AChE inhibition rates exceeding 90%. Among them, an endophytic Sporothrix isolate (...

Dereplication of Natural Products from an Endophytic Fungus from Ocotea diospyrifolia with Anti-Inflammatory Potential Through Dual Modulation of PGE2 and LTB4 Release

Endophytic fungi are significant sources of structurally diverse natural products with promising pharmacological and biological applications. In this study, endophytic fungi isolated from Ocotea diospyrifolia leaves were investigated as potential producers of anti-inflammatory natural products using an integrated workf...

GNPS-guided discovery of eremophilane sesquiterpenoids from Penicillium roqueforti and their phytotoxic activities.

The GNPS (Global Natural Products Social Molecular Networking) strategy enable the targeted isolation of eremophilane sesquiterpenoids from Penicillium roqueforti, a fungus isolated from the rhizosphere soil of Hypericum beanii N. Robson collected in the Shennongjia Forestry District, Hubei Province, China. The isolate...

Morpho-molecular approach reveals a myco-endophyte, Aspergillus novoparasiticus CBS126849 (MTCC-13997) from the roots of Capparis decidua with therapeutic and enzymatic potential

The results revealed that An-EtOAcE exhibited broad-spectrum antimicrobial effects, with maximum inhibition against E. coli, and significant α-amylase and α-glucosidase enzyme inhibition in antidiabetic activities with IC90 of 125.90 ± 1.32 and 80.60 ± 2.74 µg/mL, respectively.

Antibacterial phenolic compounds target GMPS from the endophytic Chaetomium grande-JPT2.

This is the first report on GMPS inhibition by phenolic compounds, and the binding interaction between 11 and GMPS was primarily stabilised by two hydrogen bonds formed between the hydroxyl group in 11 and amino acid residues in GMPS.