Experiments show that MKB achieves competitive scientific understanding across biological and molecular benchmarks, produces high-fidelity native outputs for weather forecasting, biological generation, and medical-image segmentation, and largely retains the general capabilities of its Qwen3-VL backbone.
Abstract
Scientific discovery is increasingly shifting from isolated disciplines to multi-domain reasoning, and AI for science faces a similar transition. Existing systems are either specialised for individual domains or unify scientific data mainly through text tokenisation and prompt-based interfaces, limiting their ability to handle diverse scientific inputs, produce modality-native outputs, and support joint understanding, reasoning, and generation across scientific domains. We introduce MKB, a unified scientific multimodal model for both understanding and generation, built around a shared Transformer backbone and modality-tailored encoders, adapters, and decoders. MKB covers six scientific branches, including DNA, RNA, proteins, small molecules, earth science, and medical images, and supports native outputs such as biological sequences, molecular strings, meteorological fields, and segmentation masks. Training follows a two-stage modality-then-language curriculum: Stage 1 aligns modality-specific components with the frozen backbone, and Stage 2 consolidates them with the language backbone using mixed scientific and general corpora. Experiments show that MKB achieves competitive scientific understanding across biological and molecular benchmarks, produces high-fidelity native outputs for weather forecasting, biological generation, and medical-image segmentation, and largely retains the general capabilities of its Qwen3-VL backbone. These results demonstrate the feasibility of the proposed paradigm, suggesting that shared-backbone models with modality-tailored components can provide a promising foundation for future cross-domain scientific multimodal exploration. The model and code are publicly available at https://github.com/Shanghai-Academy-of-AI-For-Science/MKB and https://huggingface.co/sais-org/MKB.
We present S1-Omni, a unified multimodal reasoning model for scientific understanding, prediction, and generation. AI for Science (AI4S) has advanced significantly through domain-specific models, tool-augmented LLMs, and scientific language models. However, model capabilities remain highly fragmented, limiting the joint modeling of heterogeneous data, scientific laws, and expert knowledge. S1-Omni addresses this gap by consolidating these capabilities into a single, coherent scientific reasoning model. The architecture of S1-Omni is built upon three core components: unified representation of scientific data, natural-world knowledge alignment, and decoding for domain-specific tasks. First, S1-Omni maps natural-language instructions and scientific objects, including CIF, SMILES, protein sequences, spectra, and scientific images, into a shared representation space. Second, it incorporates scientific laws and expert knowledge into data construction and training, enabling the model to reason from scientific evidence. Third, it performs task-specific decoding to support a broad range of applications, including property prediction, spectrum-to-molecular generation, protein site and structure prediction, and scientific image generation and editing. S1-Omni is trained on S1-Omni-Corpus, which covers 200 scientific tasks and contains millions of reasoning samples, and is evaluated on over 60 scientific benchmarks. It outperforms GPT-5.5 and Gemini-3.1-Pro on most benchmarks and matches or surpasses domain-specific models on several benchmarks. Overall, S1-Omni provides a practical path toward unified scientific modeling.
Jiahao Zhao, Junyi Liu, Lifeng Xu et al.· 0 citations
Multimodal large language models (MLLMs) have made it possible for artificial-intelligence systems to reason jointly across vision and language, supporting tasks ranging from image captioning and visual question answering to clinical decision support and autonomous perception. As MLLM scale grows, however, deploying these models in cost- and energy-bounded cloud environments has become a defining engineering challenge. This mini-review consolidates recent literature at the intersection of four research strands: (i) multimodal architecture design and fusion strategies, (ii) neural-activation patterns and mechanistic specialization, (iii) selective and conditional computation including mixture-of-experts, and (iv) cloud-deployment optimisation. We propose a unified four-quadrant taxonomy of efficiency strategies, trace the field's evolution through a decade-scale timeline, and synthesise sixteen primary studies in cross-cutting comparison tables. Particular attention is given to the under-explored intersection of domain adaptation and efficiency, where evidence is converging that neuron-level domain awareness can simultaneously reduce inference cost and improve interpretability. We identify five persistent limitations of current methods and five concrete research gaps that follow from them. The review closes with an integrated future-research agenda built on three converging innovations: adaptive cross-modal attention re-weighting, knowledge-injection pathways, and sparse domain-conditioned neuron gating, and outlines the cloud-aware evaluation framework that would validate them. The article is intended as a single-source reference for researchers and practitioners designing efficient, trustworthy multimodal AI for cloud deployment
Olom Ogar Austin, Joshua Abah, Ali Muhammad et al.· International journal of com...· 0 citations
This paper introduces Caduceus, a family of MoE-enhanced foundation models built with a hierarchical pre-training paradigm to jointly integrate biological and natural language, and incorporates a multi-task instruction tuning phase, enabling robust protein parsing and natural language question answering.
Mingze Yin, Yiheng Zhu, Jialu Wu et al.· Proceedings of the 32nd ACM...· 0 citations
While Multimodal Large Language Models (MLLMs) have made significant strides in visual comprehension, their ability to reason about text-dense, professional documents remains incompletely evaluated. Existing benchmarks emphasize information extraction, require external domain knowledge, or cover professional documents only as one of many settings. They are also largely English- or Chinese-centric, leaving other languages and Russian, in particular, substantially underrepresented. To address these limitations, we introduce BEAR-Bench (Bilingual Enterprise and Academic Reasoning), a self-contained, complex English-and-Russian benchmark comprising 1000 human-annotated questions based on text-rich business and scientific documents. We evaluate 16 proprietary and open-weight MLLMs, including Gemini 3.1 Pro and Qwen3.5-397B, on BEAR-Bench and observe clear headroom even for the strongest systems. Finally, we use the resulting model outputs to compare existing hallucination detection methods, evaluating not only how often models fail on BEAR-Bench but also how reliably those failures can be identified.
L. Chubarova, A. Kuleshova, D. P. Volkov et al.· 0 citations
We formulate computer vision as unified multimodal generation, where heterogeneous visual tasks are expressed in the native text and image generation spaces of a unified multimodal model, without task-specific architectures. Under this formulation, SenseNova-Vision uses natural-language instructions and optional visual prompts to specify tasks, target regions or views, and decoding conventions, and generates responses as text for symbolic outputs, images for dense spatial predictions, or mixed text-and-image outputs for compositional tasks. To support large-scale training, we convert diverse computer vision annotations into instruction-response examples compatible with these generation spaces, resulting in the SenseNova-Vision Corpus, a computer-vision instruction-response corpus spanning text, image, and mixed targets. Starting from an off-the-shelf pretrained unified multimodal model, SenseNova-Vision is trained primarily on this corpus, with auxiliary multimodal data used as a capability-preserving mixture, and requires no task-specific prediction heads or architectural modifications. The resulting model covers a broad range of vision tasks, including detection, OCR, keypoint estimation, segmentation, depth estimation, surface normal prediction, point maps, and camera pose estimation, while supporting language-defined variants that combine category, color, region, and other visual cues. Experiments show that a single unified model can match leading task-specialized systems across structured visual understanding, dense geometric prediction, segmentation, and multi-view visual geometry. These results suggest unified multimodal generation as a scalable route for integrating computer vision capabilities into general-purpose foundation models. The model and corpus are publicly available.
Xiaoyang Han, Jianhua Li, Kewang Deng et al.· 0 citations
Vision offers a critical axis for advancing foundation models, driving a shift towards natively unified multimodal pretraining. Despite this momentum, the design space and the fundamental mechanisms of how modalities interact during unified training remain underexplored. We provide empirical clarity through a systematic exploration of multimodal pretraining. Our controlled experiments on both synthetic and large-scale real-world datasets yield four key insights into the physics of multimodal pretraining: (i) Knowledge Flow: We disentangle how language, visual understanding, and visual generation transfer knowledge across modalities, revealing distinct patterns of influence and asymmetry; (ii) Synergy vs. Competition: We show that data"complexity"largely determines whether modalities are synergistic, identify architectural choices that promote synergy: such as shared attention and normalization with modality-specific feed-forward layers, and find that these behaviors generalize across different visual tokenizer designs; (iii) Early Unification: Unifying modalities from the very early stages and training them jointly is shown to be more effective than late alignment or sequential training. This process uncovers a vision laziness phenomenon, where delayed integration leads models to rely on language priors; (iv) Recipes: We derive efficient pretraining recipes that achieve strong generative performance using only 5% of the compute budget. These core findings are subsequently validated at scale by training multiple 13.5B MoE models on 2T tokens. We hope this study provides a principled foundation for understanding and scaling multimodal pretraining.
Junlin Han, Shengbang Tong, David Fan et al.· 0 citations