Significant advances in integrated strategies, particularly organelle engineering in Yarrowia lipolytica and Saccharomyces cerevisiae, have increased squalene titers to high levels and provide a useful basis for future metabolic engineering efforts aimed at improving squalene production and facilitating the synthesis of related terpenoids.
Oleanane-type pentacyclic triterpenoids are a class of naturally occurring specialized metabolites with diverse biological activities. Conventional plant extraction and chemical synthesis are constrained by low yields, high costs, and a reliance on natural resources. With the development of synthetic biology and meta...
Fu-Yan Yuan, De-Yue Diao, Shi-Xiang Peng et al.· Journal of Agricultural and...· 0 citations
Polyketides are among the most structurally diverse and therapeutically important classes of natural products, serving as antibiotics, anticancer agents, agrochemicals, and industrial pigments. Their structural complexity and limited natural availability have driven the development of microbial biosynthetic platforms a...
Tryptophan-derived metabolites are indole-containing compounds with applications in medicine, functional foods, and agriculture. Conventional production via plant extraction or chemical synthesis is often inefficient and unsustainable, prompting the development of microbial biosynthesis. In this review, these metabolit...
Chen-Xi Qiu, Hong-Wei Guo, Quan-Pu Ren et al.· Journal of Agricultural and...· 0 citations
2-Phenylethanol (2-PE) is a valuable aromatic alcohol known for its rose-like scent, widely used in the fragrance, food, and cosmetics industries. The growing demand for “natural” certified products is driving increasing interest in microbial fermentation as a sustainable and promising alternative to chemical synthesis...
Yi-Bo Ning, Chang-Tong Lu, Qing-Fu Wang et al.· Frontiers in Microbiology· 0 citations
This review systematically summarize recent progress in the metabolic engineering of Candida species as microbial cell factories, with particular emphasis on expanding genetic toolkits, utilizting renewable and non-conventional carbon sources, and biosynthesizing high-value compounds.
