This work analysed 939 cyanobacterial genomes spanning 11 orders and five habitat types to identify taxonomic and ecological hotspots of biosynthetic potential and link phylogeny, ecology and genomic features to prioritise taxa, habitats and biosynthesis pathways for future natural product discovery.
Comparative genomic and biosynthetic analyses of 24 Talaromyces species reveal extensive diversification alongside selective conservation of secondary-metabolite pathways across Talaromyces and provide a genomic framework for prioritizing species and BGCs for antifungal natural-product discovery and biocontrol-oriented...
B. Chellappan, Hashem Al-Sheikh· Journal of Fungi· 0 citations
Genomic and metagenomic studies have revealed that microbes have the capacity to produce an enormous diversity of secondary metabolites. These compounds play important roles in microbial interactions and are also a major source of medicines and other useful natural products, yet only a small fraction of this biosynthet...
Caner Bağcı, Alec Talamas-Tanner, N. Ziemert· bioRxiv· 0 citations
It is demonstrated that environmental filtering shapes both the taxonomic and functional organization of Antarctic microbiomes and highlight polar ecosystems as reservoirs of unexplored biosynthetic diversity with potential biotechnological relevance.
William B. Medeiros, Kelly Hidalgo-Martinez, D. D. P. S. Penna et al.· World Journal of Microbiolog...· 0 citations
Rare actinobacteria are promising sources of specialized metabolites, yet genome mining still prioritizes genomes encoding many biosynthetic gene clusters (BGCs) rather than clusters that are distant from characterized chemistry. Here, we describe the isolation of a novel Jiangella strain reported from a marine, animal...
Ruggero Baviera, F. Capri, Paola Galluzzo et al.· Marine Drugs· 0 citations
It is demonstrated that microbial adaptation to extreme environments favors RiPP-based biosynthesis and that HCN may play a role in archaeal ecological interactions, and microbial communities in Arctic hydrothermal vent biofilms provide a rich reservoir of unique bioactive compounds, with implications for drug discover...
Thuc Trong Nguyen, I. H. Steen, R. Stokke· Nature Communications· 0 citations
The effectiveness of integrated genome-mining strategies for prioritizing cryptic biosynthetic gene clusters is demonstrated and the remarkable biosynthetic potential of newly identified Streptomyces isolates as a source of novel natural products is highlighted.
Nada S. Al-Theyab, Haila M. Alnassar, Mohanad A. Ibrahim et al.· Frontiers in Microbiology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
