This approach provides a robust framework for developing highly effective antimicrobial regimens based on peptide synergy and the sensitization of MDR pathogens, thereby expanding the therapeutic spectrum of clinically vital antibiotics against drug-resistant infections.
A holistic overview of the latest research on the antimicrobial activity and synergy of herbal plant extracts on carbapenem-resistant Escherichia coli and multidrug-resistant clinical isolates is discussed, revealing a glimpse of their potential as next-generation antimicrobials.
Sandhya, Amit Kumar, Bijendra Singh et al.· Progressive Agriculture· 0 citations
The efficacy of antibiotics is increasingly limited by microbial resistance, necessitating the development of alternative therapeutic strategies. The combination of conventional antibiotics with antimicrobial peptides (AMPs) has emerged as a promising approach for enhancing antibacterial activity. Listeria monocytogene...
Jonggwan Park, Da Dam Kang, Yu-Jin Lim et al.· Journal of Peptide Science· 0 citations
The growing occurrence of antimicrobial resistance represents a major challenge to global healthcare and necessitates the development of novel therapeutic agents capable of overcoming multidrug-resistant (MDR) pathogens. Gramicidin S (GS), a cyclic decapeptide antibiotic has attracted renewed interest as a promising te...
T. S. Shkuratova, Daria V. Andreeva, A. Tikhomirov et al.· Future Medicinal Chemistry· 0 citations
ICAC may potentiate the antibacterial activity of ciprofloxacin through targeting of OmpF, which disrupts bacterial membrane integrity and energy metabolism, providing a promising candidate strategy for combating infections caused by the tested antibiotic-resistant E. coli.
Yu-Bin Bai, Xu Chen, Rong-Bin Hu et al.· Biomolecules· 0 citations
Antimicrobial resistance demands new strategies capable of restoring the effectiveness of conventional antibiotics. In this study, the antibacterial activity and adjuvant potential of five Meldrum’s acid derivatives (MAD1–MAD5) against multidrug-resistant strains of Staphylococcus aureus 10 and Escherichia coli 06 were...
I. M. Araújo, Ewerton Yago de Sousa Rodrigues, D. S. Alves et al.· International Journal of Mol...· 0 citations
Background: Antimicrobial resistance is at alarming levels. Methicillin-resistant Staphylococcus aureus is a clinical concern and has been classified as one of the so-called ESKAPE pathogens. The increase in resistance coupled with the lack of new agents in development requires innovative ways of developing new antimic...
Ed Siegwart, Ajay Mistry, John George· Antibiotics· 0 citations
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