Integrated multi-omics and functional analyses reveal a GDCA-TGR5-mediated immunometabolic signature in anorexia nervosa

Yan-Bo Sun Cong-Hui Xu Jing Luo Yun-Yun Cen Shengguo Zao Li-Jin Zhou Yu-Yue Cao Yan-Li Li Wei-Ming Li

Aug 2026 · European Archives of Psychiatry and Clinical Neuroscience · Vol 276, pp. 3975 - 3993 · 0 citations · 59 references

Medicine

TL;DR

Findings suggest that metabolic alterations in AN directly influence immune regulation, and a novel metabolic-immune pathway with therapeutic potential in AN is revealed.

DOI PubMed Semantic Scholar

View source

Similar papers

Open access Aug 2026

ZBTB16-associated NK cell alterations reveal shared immunometabolic signatures linking primary Sjögren’s syndrome and type 1 diabetes mellitus

Findings provide evidence for shared molecular and immunological signatures underlying the two autoimmune disorders and support further investigation of the biological role and diagnostic value of ZBTB16 in pSS and T1DM.

Ming-Zhe Xin, Rui Mu, Yuxin Qian et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Multi-omics integrated with machine learning identifies LPS-related genes potentially associated with iron metabolism-Immune axis imbalance in PCOS: a bioinformatics-based exploration of mechanisms and diagnostic markers

A potentially previously unrecognized association among lipopolysaccharide-related genes, iron metabolism imbalance, and immune dysregulation in polycystic ovary syndrome is suggested, thereby providing a potential framework for future mechanistic investigations and the development of diagnostic and therapeutic targets...

Yang Li, Chunmei Bai, Xumin Zhang et al. · Scientific Reports · 0 citations

Open access Jul 2026

Integrative multi-omics analysis unravels the metabolic landscape and reveals serum biomarkers for early diagnosis of hyperuricemia

The core metabolic and protein regulatory networks of HUA are revealed, and a novel serum metabolite panel for the diagnosis of HUA is identified, providing new insights for improved clinical diagnosis and management.

Xin Sun, Baoying Gong, Ye Sun et al. · Metabolomics · 0 citations

Open access Jul 2026

A multi-omics framework integrating gut microbiota, blood metabolites, and immune cells to elucidate the pathogenesis of Alzheimer’s disease

A regulatory network underlying the AD microbiota–metabolite-immune-brain axis is mapped and core genes with potential diagnostic and therapeutic value are identified, supporting a systems-level view of AD that may inform precision medicine strategies.

Bei Wang, Wei Yan, Yu-Sheng Zhang · Frontiers in Immunology · 0 citations

Open access Jul 2026

Unveiling the aging-immune axis in irritable bowel syndrome: a multi-omics and machine learning approach to biomarker discovery and validation

Immune infiltration analysis uncovered a distinct immune landscape in IBS, with significant correlations between biomarker expression and immune cell populations, with significant correlations between biomarker expression and immune cell populations.

Yi Yao, Jingping Li, Bo Zhang et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Integrative multi-omics analysis identifies AIF1 as an immune-associated factor linked to monocyte-centered inflammatory networks in Alzheimer's disease.

An integrative multi-omics analysis combining Mendelian randomization, bulk transcriptomics, single-cell RNA sequencing, and peripheral blood validation identifies AIF1 as an immune-associated factor linked to genetic and transcriptional alterations in AD and suggests its association with monocyte-related immune states...

Qian Li, Ming-Jian Li, Xi Huang et al. · Immunobiology · 0 citations