TL;DR
The gut microbiota and its metabolites may be associated with the immune microenvironment and tumor progression in CESC, potentially involving the MIF signaling axis.
A systems biology approach integrating gut microbial metabolite annotation, metabolite-associated gene identification, transcriptomics validation, network topology analysis, immune infiltration profiling, and single-cell transcriptomic datasets to investigate potential metabolite-host interactions associated with lung...
A comprehensive framework for microbiome-host interactions in BLCA is established, identifying Paenibacillus and Prevotella as opposing microbial orchestrators of tumor biology, and advance bladder cancer microbiome research from descriptive taxonomy toward the development of mechanistic, clinically actionable biomarke...
At single-cell resolution, ZBTB21 emerges as a metabolic regulator that strengthens serine biosynthesis and redox homeostasis and provides mechanistic insights and potential strategies for metabolic-targeted therapies in CRC.
The four‐gene signature and characterization of Neutrophil_IFITM2, supported by independent qRT‐PCR validation and preliminary IFITM2 knockdown experiments, may provide a framework for precision diagnosis and future mechanistic studies in UC.
Dysregulated metabolic pathways and key microbe-metabolite crosstalk are closely associated with CRC progression, offering novel non-invasive biomarkers and premalignant intervention targets.
This study delineates distinct alterations in the gut microbiota and serum metabolomic profiles of EC patients, identifying Megamonas and Klebsiella as promising non-invasive predictive biomarkers.
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