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Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery

Oluwatosin A. Olayinka John J. Farrell Cong-Cong Zhu Z. Khurshid Eden R. Martin William S. Bush M. Pericak-Vance Li-San Wang G. Schellenberg J. Haines K. Lunetta Xiao-Ling Zhang L. Farrer

Aug 2026 · Alzheimer's & Dementia · Vol 22 · 0 citations · 48 references

Medicine

Abstract

We utilized an Alzheimer's disease (AD) polygenic risk score (PRS) to discover associations with novel rare variants (RVs).

DOI PubMed Semantic Scholar

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