Analysis code for "Relative fat mass and an obstructive sleep apnea-related symptom phenotype among U.S. adults: a cross-sectional NHANES study"

Abstract

This record contains the reproducible R analysis code and aggregate reference outputs supporting the manuscript “Relative fat mass and an obstructive sleep apnea-related symptom phenotype among U.S. adults: a cross-sectional NHANES study.” Version 2.0.0 is the code release accompanying the second revision. The package reconstructs the analytic cohort from public-use NHANES 2005–2006, 2007–2008, 2015–2016, and 2017–2018 files and reproduces cohort flow, cycle-specific variable harmonization, complex-survey regression, primary sex-stratified and secondary pooled analyses, symptom-threshold and restriction sensitivities, subgroup interactions with multiplicity adjustment, covariate-only multiple imputation with finite-sample degrees of freedom, natural-spline analyses, proxy-exclusion and calendar-era analyses, and JKn survey-replicate AUC estimates and paired differences with model refitting. Conventional unweighted DeLong analyses are retained only as an exploratory sensitivity. Raw NHANES XPT files and row-level participant data are not redistributed. The scripts retrieve the public-use source files directly from CDC/NCHS. The archive includes complete environment-setup instructions and a one-command analysis runner, tested software/session information, an explicit required-output manifest, aggregate machine-readable reference tables, checksums, and verification reports. The code is released under the MIT License.