Aug 2026· Nature Reviews Endocrinology· 0 citations· 101 references
Medicine
TL;DR
Progress in the understanding of ATC biology is highlighted, with a focus on driver genetic alterations, metabolic plasticity and microenvironmental interactions that underpin its exceptional aggressiveness, to provide a rationale for the design of multimodal therapeutic strategies urgently needed to improve outcomes for patients with ATC.
The principal mechanistic programs that define the ATC phenotype are described: disruption of cell-cycle and apoptotic control through alterations in TP53, CDKN2A/B, and aberrant MAPK activation; metabolic adaptations involving glycolysis, glutaminolysis, and mitochondrial one-carbon metabolism; reprogramming of canoni...
Anthony Centone, N. DeSouza, Nan Yang et al.· International Journal of Mol...· 0 citations
Collectively, the advances are an indication of a transition to the personalized, mechanism-driven treatment strategies that would prolong the survivability of patients with advanced thyroid cancer, conquer resistance, and reduce systemic toxicity.
Tanmoy Sarkar, Ruhi Arisha, S. Sengupta et al.· Clinical and Translational O...· 0 citations
A 23-gene expression signature was built to predict metastasis from primary cSCC tissue, and this findings provide the most detailed molecular portrait of cSCC to date and establish an assay for risk stratification suitable for clinical implementation.
B. Rentroia-Pacheco, Harsh Sharma, L. Pozza et al.· medRxiv· 0 citations
This study comprehensively maps the coevolution of malignant thyrocyte plasticity and the immunosuppressive metastatic niche in thyroid cancer and provides a robust molecular rationale for developing next-generation immunotherapeutic strategies tailored to thyroid cancer.
Shu-hang Xu, Yaorong Su, Senmin Zhang et al.· Oncoimmunology· 0 citations
This review synthesizes the genomic and multi-omics determinants of thyroid cancer management across diagnosis, risk stratification, treatment selection, resistance monitoring, and follow-up, and discusses the practical barriers that continue to limit routine implementation.
Dhoha Dhieb, Kholoud Bastaki· International Journal of Mol...· 0 citations
This comprehensive review highlights BMBC resistance mechanisms, drawing from preclinical models, clinical studies, and genomic analyses, and highlights the potential for personalized, multi-targeted approaches to improve patient outcomes in BMBC.
Paromita Sarker, Shreyas S. Rao· Biochimica et biophysica act...· 0 citations
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