A comprehensive review aims to consolidate the current understanding of cellular senescence and its pathological consequences, and presents an in-depth analysis of studies employing nano-drug delivery systems in cellular senescence research, emphasizing their potential role and prospects.
Abstract Aging is a complex biological process that leads to a growing burden of age-related diseases (ARD). Cellular senescence, which involves irreversible cell cycle arrest and the release of senescence-associated secretory phenotype (SASP), plays a central role in aging and the development of ARD. Natural extracell...
Shi-Jie Lv, Ji-Rong Xie, Xin Huang et al.· International Journal of Nan...· 0 citations
Cellular senescence is an important factor which significantly impairs the homeostasis and regeneration capability of skin through causing chronic inflammation, degradation of the extracellular matrix, depletion of stem cells, and angiogenesis impairment. In addition to the already known senescence associated secretory...
Barathan Muttiah, G. Venkatraman· Journal of drug targeting (P...· 0 citations
Ovarian cancer develops within a biological environment that changes substantially with age. Beyond chronological aging, progressive alterations in genome maintenance, telomere integrity, epigenetic regulation, mitochondrial function, metabolism, inflammation, and immune surveillance can reshape the cellular and tissue...
Yu-Bo Zhang, Yue Han, Pin-Zhi Hou et al.· Frontiers in Pharmacology· 0 citations
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease where chronological aging predicts the conversion to progressive MS (PMS), a phase defined by compartmentalized inflammation and accelerated neurodegeneration. While current disease modifying therapies (DMTs) are effective for managing the inflamma...
Ala' Yousef, John M. Seubert, Christopher Power et al.· Frontiers in Immunology· 0 citations
The global rise in life expectancy has led to an increasing prevalence of age-related diseases, including neurodegenerative disorders, cancer, type 2 diabetes mellitus, and cardiovascular conditions, placing substantial societal and economic burdens on healthcare systems worldwide. A key mechanism underlying both aging...
Lukas Fresser, Zofia Chrienova, Jan Gebrt et al.· Frontiers in Pharmacology· 0 citations
This study critically examines how viral and bacterial agents induce cellular senescence, particularly in vitro, reviewing the regulatory mechanisms involved and discusses genetic variants affecting infection susceptibility and categorizes senescence markers.
E. V. Simoroz, Y. V. Antonov, G. Muravyov et al.· Vavilovskii zhurnal genetiki...· 0 citations
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