Amyloidogenic Amylin Signaling Links Diabetes to Dementia Pathogenesis

Abstract

Recent studies identify amyloidogenic human amylin, secreted from pancreas, as a potential link between type-2 diabetes and Alzheimer’s disease. Evidence suggests that pathogenic amylin signaling impairs cerebral bioenergetics, promoting tau hyperphosphorylation and neurodegeneration. Selective targeting of circulating amyloidogenic amylin and its pathogenic signaling may enable biomarker development and disease-modifying therapies.