Heterogeneity of GFAP Expression in Alzheimer’s Disease: A Perspective from the Vascular-Inflammation Axis

Abstract

Based on the “vascular-inflammation axis” analytical framework, this study evaluates the pathophysiological significance of plasma glial fibrillary acidic protein (GFAP) in Alzheimer’s disease (AD). We systematically analyze its expression heterogeneity and clinical interpretive boundaries, specifically comparing late-onset AD (LOAD) and early-onset AD (EOAD).