TL;DR
Although a PSA density threshold of 0.125 demonstrated only modest discriminative ability, PSA density may provide additional information as an adjunct to preoperative risk assessment among surgically treated patients.
Several MRI-derived parameters, including capsular contact length, MRI-suspected extraprostatic extension, and urethral proximity, were associated with an increased likelihood of positive surgical margins, and incorporation of these metrics alongside clinical factors may improve risk stratification.
Simple Summary Selecting men with ISUP Grade Group (GG) 2 prostate cancer for active surveillance remains challenging. In this Flow, 10% (and up to 15% in selected cases) combined with low PSA density reliably identifies organ-confined, non-upgraded pathology. These quantitative thresholds provide objective criteria to...
Introduction: Discrepancy between the assessment of prostate cancer (PCa) grade based on biopsy and the final pathological findings after radical prostatectomy (RP) remains a significant challenge in preoperative risk stratification, particularly among patients diagnosed with low-risk disease. Accurate identification o...
OBJECTIVE To evaluate the incidence, clinicopathological characteristics, and impact on overall survival (OS) of incidental prostate cancer (iPCa) detected in patients undergoing radical cystoprostatectomy (RCP) for bladder cancer. MATERIALS AND METHODS We retrospectively analyzed data from 395 male patients who unde...
BACKGROUND Prior studies in the pre-MRI era suggest that patients with NCCN Intermediate and High Risk Grade Group 1 prostate cancer (GG1 PCa) on biopsy have increased risk for adverse oncologic outcomes. However, prostate MRI has altered patient selection for biopsy and improved prostate sampling. Herein, we examined...
Background and Objectives: Multiparametric magnetic resonance imaging (mpMRI) is widely used in prostate cancer diagnosis, but biopsy findings may still underestimate tumor aggressiveness. This study evaluated the association of Prostate Imaging Reporting and Data System (PI-RADS) assessment with clinically significant...
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