Aug 2026· Frontiers in Drug Safety and Regulation· 0 citations· 33 references
TL;DR
This perspective examines recent developments in AI for PV and introduces a conceptual framework of “computable PV,” in which tasks are evaluated based on their computational tractability and suitability for automation.
Abstract
Advances in generative artificial intelligence (AI), particularly large language models (LLMs), have sparked discussions in automating pharmacovigilance (PV) workflows. It remains unclear whether these technological advancements fundamentally change the prior conclusions that full automation of Individual Case Safety Report (ICSR) processing is not feasible.
This perspective examines recent developments in AI for PV and introduces a conceptual framework of “computable PV,” in which tasks are evaluated based on their computational tractability and suitability for automation.
Routine, well-defined PV tasks, including completeness checks, detection of duplicated ICSRs, and structured information extraction, are increasingly amenable to automation. In contrast, complex activities such as case-level causality assessment remain difficult to formalize and continue to rely on expert judgment. The emergence of LLMs enables broader, cross-task capabilities compared to traditional task-specific, “small” models, but introduces challenges related to reliability, auditability, and governance. As a result, hybrid architecture combining large models, small models, and rule-based components is increasingly necessary.
Generative AI, as of today, does not signal full automation of PV but rather shifts toward hybrid human-AI systems. While AI can augment efficiency and support evidence synthesis, final decisions must remain under human oversight. Future PV systems should prioritize transparency, validation, and the integration of AI outputs into expert-driven decision-making.
FLARE is proposed, a novel framework that endows VLAs with robust error recovery capabilities through a ``Retry" and ``Reset" Paradigm, and significantly improves task success and robustness.
Ganlong Zhao, Zijia Tang, Xingping Chen et al.· 3 citations
LifeSciBench is introduced, a benchmark of 750 expert-authored tasks designed to evaluate whether language models can handle realistic life science research work, with each constituent task paired with a human expert-written rubric.
Amelia Liu, Andrew Ho, Anne Marie Droste et al.· bioRxiv· 2 citations
Experimental results show that CritICL consistently outperforms standard in-context learning and achieves performance competitive with or superior to test-time scaling methods, while requiring significantly fewer generations and lower token cost.
Yu-Fan Wu, Yinghui He, Zhengyi Hu et al.· 1 citation
TestifAI, a deep learning testing framework for efficient and accurate estimation of robustness against combinations of perturbations, is proposed and partial model tomography is introduced, a novel approach to reconstructing model behaviour in a multi-perturbation space from tests that apply only a small number of perturbations.
Arooj Arif, T. Hartung, E. Botoeva et al.· 1 citation
The complex multi-energy coupling characteristics inherent to integrated energy system (IES) present unprecedented challenges for the implementation of low-carbon scheduling. Existing optimization methods often exhibit limitations in system scalability, algorithm adaptivity, and carbon reduction efficacy for complex IES. This paper proposes a Large Language Model (LLM)-Embedded Multi-Agent Reinforcement Learning (LEMARL) to address the aforementioned issues. The proposed method integrates the global perception capability of LLMs with the dynamic optimization capability of MARL. Specifically, the LLM-Embedded module generates high-quality reward functions and policy frameworks from a global perspective, while the MARL module leverages these LLM-generated strategies for distributed interactive iterations—greatly enhancing computation efficiency and scalability. Simulation results demonstrate that LEMARL reduces carbon emissions by 7.76% and simultaneously decreases operating costs by 4.49% in a small-scale IES. Furthermore, LEMARL also exhibits superior applicability and scalability in large-scale IES of the IEEE 141-bus power grid integrated with 51-node thermal system.
Chen Xia, Tong Gou, Yinliang Xu et al.· IEEE Transactions on Smart G...· 1 citation
General-purpose language models can reason and synthesize knowledge, but complex work also requires sustained interaction with files, information sources, and executable code, together with state maintenance, failure recovery, and verifiable delivery. We call this \emph{working capability}: sustained, verifiable progress toward a real-world objective. Apodex 1.1 develops this capability along two complementary dimensions. \emph{Environment Scaling} expands the diversity and verifiability of executable file, search, and code environments, while \emph{Agentic Coordination Scaling} trains agents to decompose long-horizon tasks, delegate parallel work, integrate asynchronous results, and replan. A shared execution harness and AgentOS maintain task state and provenance across tools and agents, and training turns environment trajectories and coordination traces into reliable behavior. Across complex professional work, finance, scientific research, mathematics, coding, and search, Apodex 1.1 reaches the leading performance band despite using a substantially smaller model than many frontier systems. The 35B-parameter Apodex 1.1 Mini further retains strong working capability in a locally deployable form. These results ground agentic intelligence in useful, verifiable work completed over time and advance our goal of building a \emph{Heavy-Duty Solver} for ambitious, long-running tasks.
Apodex Team B. An, B. Li, B. Wang et al.· 1 citation
A new method for surgically removing training examples from a model reveals that as datasets grow, the link between what a model learns and what it produces dissolves.
