This scientific commentary refers to ‘White matter lesions disrupt cholinergic pathways important for cognition in Parkinson’s disease’ by Carli et al. (https://doi.org/10.1093/brain/awag172).
Cholinergic white matter pathway degeneration is central in Alzheimer's disease and Lewy body disease and can be assessed in vivo using magnetic resonance imaging proxies, but neuropathological validation is limited.
The dual syndrome hypothesis distinguishes frontostriatal and posterior cortical cognitive subtypes in Parkinson's disease with mild cognitive impairment (PD‐MCI), which are associated with distinct cognitive profiles and different risks of dementia.
[This corrects the article DOI: 10.3389/fresc.2026.1851559.].
White matter (WM), as the critical infrastructure for neural communication, is implicated in pediatric bipolar disorder (PBD) pathophysiology. However, the state‐specific abnormalities in the segmental structural and functional properties of adolescent fiber tracts remain unclear.
We tested whether quantitative transport mapping (QTM)‐derived perfusion velocity would detect earlier and more sex‐specific microvascular alterations than cerebral blood flow (CBF) across the Alzheimer's disease (AD) continuum.
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